A portion of a multi-paneled, gold-leaf painting by Takashi Murakami presides over the living room, set into a niche created by architect Benoit Dupuis above a custom banquette designed by Cathy Vedovi, vintage Roger Capron cocktail tables, and Jules Leleu armchairs.

A pair of vividly hued Alex Hubbard paintings, including this untitled 2011 work, animate the living room.

A doughnut-shaped sculpture by Nathalie Djurberg takes center stage on the dark chevron floor.

For the entry, Dupuis devised a sunburst-pattern marble floor and mirrored doors. Artworks by Hans Hartung (left) and Pamela Rosenkranz are joined by 1960s FontanaArte side tables; a small piece by Damien Hirst hangs above a Franck Evennou console.

Vedovi used a vintage ceramic vase to create the lamp on the living room’s circular end table; the rug is by Edward Fields.

In another area of the room, a Hans Hartung painting hangs above a tufted brown banquette and a 1980s Lothar Klute cocktail table next to a ’70s screen clad in eel skin.

In the living room, Roger Thibier chairs surround a 1970s Paco Rabanne table; a Jean-Michel Atlan painting hangs to the left of the marble fireplace designed by Dupuis and outfitted with circa-1930 andirons by Anton Prinner.

Hand-stenciled bamboo-pattern wallpaper by Ulgador provides a striking backdrop for a Takashi Murakami painting in the dining room, which Vedovi furnished with a 1960s Ramsay table, Jansen chairs, and a rug by Jean Picart Le Doux.

Vibrant pieces by Japanese artist Takashi Murakami can be found throughout the home. “His work is classic but in a futuristic way,” says Vedovi. “There’s a cosmic movement to it.” This small vinyl sculpture, Mr. DOBtopus A (2017), illustrates the artist’s irreverent spirit.

To complement the frenetic Murakami panel, the dining room is sheathed in mirrors and gilded bamboo-print wallpaper made by artisans at French atelier Ulgador. “I needed to bring a more traditional touch to the room,” explains Vedovi. “And because there were no windows, I added

Paintings by Alex Hubbard (left) and Georges Rouault overlook the living room’s red curved banquette and ottoman, which were formerly in the Ritz Paris hotel’s Bar Vendôme; a vintage ceramic lamp stands on a side table by Eric Schmitt, who also designed the cocktail table.

In the main bedroom, a Takashi Murakami work is mounted over the custom-made Tessilarte bed, which is dressed with Pierre Frey bedding and flanked by vintage American tables topped by Jansen lamps; the table at the foot of the bed is also by Jansen.

The travertine-lined main bath’s vanity, designed by Dupuis with Watermark Designs fittings, is furnished with a Baguès stool.

The bath, which retains its original Jansen-designed mirror doors, also features a Bette tub.

A masterful canvas by Japanese painter Akira Tanaka, who worked largely in Paris and was inspired by quotidian moments, hangs in the guest bedroom. The Tessilarte bed, meanwhile, is dressed in bedding by Pierre Frey.

Vedovi discovered the guest bedroom’s Paul Evans console at a Rago auction and paired it with the client’s ethereal canvas by French artist André Masson. “There’s something about the console that’s reminiscent of trees, even though it’s made of metal,” she says. “It’s a great combination.”

In the kitchen, designer Cathy Vedovi mounted a pair of Georges Jouve sconces on a dazzling grid of turquoise wall tiles crafted by Portuguese ceramic atelier Barro. “The sconces came first, then I tried to find what would go well with them,” she explains. “These tiles are like diamond points, which relate to the floor in the entrance.”

This project marked the first design collaboration between Vedovi and architect Benoit Dupuis, whose clients include Keith Richards and Christian Louboutin. “It was a dream to work with him,” she says. “He is very humble and, like me, doesn’t have an ego. If he has a better idea, I’m just as happy because we all win.”