Artist Isamu Noguchi and architect Wallace K. Harrison’s 1940 design for a glass-and-birch house, the sinuous lines of which echo the Maine coast on which it sits, embodied the concept “site-specific” long before the term was popularized. In the late ’90s, however, the dazzling dwelling completely burned to the ground, and the owners enlisted a trio of talents to rebuild an exact replica in its stead: contractor Dan McGraw of Atlantic Builders; sculptor and woodworker Mark Loftus, who re-created Noguchi’s dining table (shown); and master woodworker Jim Robinson.

Conceived in collaboration with Kovac Design Studio, the Los Angeles home of Lori Kanter Tritsch and her partner, William P. Lauder of the Estée Lauder Companies, features sliding glass walls that open up to spectacular views.

In the ritzy Trousdale Estates section of Beverly Hills, designers James Magni and Jeremy Graef crafted a minimalist refuge for kombucha mogul G.T. Dave. Located adjacent to Dave’s residence, the immaculate entertaining pavilion designed by the team enjoys spectacular views overlooking Los Angeles out to the Pacific Ocean and boasts a dynamic collection of blue-chip art by the likes of Anish Kapoor, Sterling Ruby, Antony Gormley, Chris Burden, and Jaume Plensa.

Surrounded by water and protected landscape, this breathtaking Hamptons residence was crafted by Leroy Street Studio and decorated by Victoria Hagan, who seamlessly integrated major artworks by El Anatsui and Maya Lin into the design. Sheathed in gray-gold Palestinian limestone, the dramatic architecture is accompanied by an outdoor infinity pool as well as sweeping views of the Southampton shoreline.

Perfectly reflecting the subtle palette of the surrounding desert landscape, this modern masterpiece in Palm Springs is the vision of Southern California architecture firm Marmol Radziner. Pictured is one of the abode’s corridors, in which shadows cast a graphic pattern against a site-specific installation by artist Phillip K. Smith III, made of mirrored glass and LED lights, which changes color throughout the day. The Azadeh Shladovsky rosewood-and-sheepskin bench is from Jean de Merry.

For her serene Palm Beach escape, designer Lillian Fernandez sought inspiration from a modernist seaside villa conjured by Hugh Newell Jacobsen in Casa de Campo, a secluded oasis in the Dominican Republic where her family has a retreat. To help realize her vision, she called upon local architects Stephen Roy and Virginia Dominicis, as well as designer Fernando Wong, providing them with a succinct set of directives for an artful one-bedroom house, plus a separate guesthouse, emphasizing connections to the outdoors.

Architect William T. Georgis revamped this midcentury marvel in Southern California that was originally designed by Homer Delawie, a venerated regional architect. Dating to 1963, the revived post-and-beam house now features a stunning collection of art, including works by George Condo, Kenny Scharf, and Tom Sachs (shown).

Major art collectors Linda and Jim Lippman tapped architect Steve Giannetti and designer Anna Busta to conceive this stunning residence at the Madison Club in La Quinta, near Palm Springs. Adding visual punch to the entrance gallery are one of Anish Kapoor’s concave mirror works, a painting by Willem de Kooning, and a Richard Hudson sculpture displayed atop an Atelier Viollet table; an Alison Berger bench rests beneath the floating staircase, designed by Giannetti.

Known for his muscular brand of architecture, Seattle-based Tom Kundig conjured the Rimrock House perched on a basalt ledge overlooking Washington State’s winding Spokane River. Clad primarily in weathered steel, the cliffside dwelling is as breathtaking as its woodland surroundings. Kundig even likens the home to “a Tootsie Pop—hard on the outside, soft on the inside.”

As America’s most beloved architect, Frank Lloyd Wright devised hundreds of buildings across the country from the 1890s to the 1950s, deploying an uncanny ability to distill a site’s essence into pragmatic structures that never skimped on aesthetics. For the David and Gladys Wright home in the Arizona desert, the architect incorporated elements of his Usonian ideal to conjure a “A Modern Castle in the Air,” as House Beautiful magazine dubbed it in 1955. The interiors are no less stunning, with floor-to-ceiling windows, concrete floors, and a mahogany ceiling, all of which have been graciously preserved by the current owners.